Hmm...
I'd have to say my top choice is not from real life...but from within a game.
I shudder(ed) everytime I hear(d) Sindragosa (World of Warcraft) say '[SPAN class=text-yell]Suffer, mortals, as your pathetic magic betrays you!'[/SPAN]
[SPAN class=text-yell][/SPAN]
[SPAN class=text-yell]THAT'S more annoying over Fran Drescher (The Nanny) imo.[/SPAN]